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Systemic Anti-Cancer Therapy Regimen Library

Home > LEU ALL - UKALL14 [40 years and under] > LEU - UKALL14 Maintenance
This regimen is a component of LEU ALL - UKALL14 [40 years and under]

UKALL14 [40 years and under] - Maintenance (LEU ALL - UKALL14 [40 years and under])

Treatment Overview

NOT to be used for transplant patients.


Starts after count recovery from Consolidation Cycle 4, with neutrophils greater than 0.75 x 109/L and platelets greater than 75 x 109/L.


Dosing of Maintenance therapy should be adjusted to maintain:

  • Neutrophil count between 0.75 and 1.5 x 109/L.
  • Platelet count between 75 and 150 x 109/L.

Cycles 1 to 8 - 84 days

Cycle length:
84

Intrathecal metHOTREXATe:

  • May be administered during Maintenance if neutrophils greater than 0.75 x 109/L and platelets greater than 75 x 109/L.
  • For Ommaya reservoir reduce dose to 6 mg intraventricularly.

mercaptOPURine:

  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Oral metHOTREXATe:

  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Avoid trimethoprim + sulfamethoxazole on the days oral metHOTREXATe is administered.

Cycle details

Cycles 1 to 8 - 84 days

Medication Dose Route Days Max Duration
vinCRISTine 1.4 mg/m² Cap dose per administration at: 2 mg intravenous 1 10 minutes
metHOTREXATe 12 mg flat dosing intrathecal injection 1
prEDNISone 60 mg/m² Once daily oral administration 1 to 5
mercaptOPURine 75 mg/m² Once daily oral administration 1 to 84
metHOTREXATe * 20 mg/m² Once a week oral administration 1, 8, 15,
22, 29, 36,
43, 50, 57,
64, 71, 78

Intrathecal metHOTREXATe:

  • May be administered during Maintenance if neutrophils greater than 0.75 x 109/L and platelets greater than 75 x 109/L.
  • For Ommaya reservoir reduce dose to 6 mg intraventricularly.

mercaptOPURine:

  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Oral metHOTREXATe:

  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Avoid trimethoprim + sulfamethoxazole on the days oral metHOTREXATe is administered.

Full details

Cycles 1 to 8 - 84 days

Day: 1

Medication Dose Route Max duration Details
vinCRISTine 1.4 mg/m² Cap dose per administration at: 2 mg intravenous 10 minutes
Instructions:
  • Diluted in a minibag.
  • FOR INTRAVENOUS USE ONLY – fatal if given by any other routes.
  • Warning vesicant—ensure vein is patent prior to administration, administer vesicant as per institutional policy and monitor for signs of extravasation throughout administration.
metHOTREXATe 12 mg flat dosing intrathecal injection
Instructions:
  • May be administered during Maintenance if neutrophils > 0.75 x 109/L and platelets > 75 x 109/L.
  • Adhere to local institution policy for intrathecal administration
  • For Ommaya reservoir reduce dose to 6 mg intraventricularly
prEDNISone 60 mg/m² Once daily oral administration
Instructions:

Take in the morning with food.
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
metHOTREXATe * 20 mg/m² Once a week oral administration
Instructions:
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 2.5 mg tablets.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 2

Medication Dose Route Max duration Details
prEDNISone 60 mg/m² Once daily oral administration
Instructions:

Take in the morning with food.
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 3

Medication Dose Route Max duration Details
prEDNISone 60 mg/m² Once daily oral administration
Instructions:

Take in the morning with food.
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 4

Medication Dose Route Max duration Details
prEDNISone 60 mg/m² Once daily oral administration
Instructions:

Take in the morning with food.
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 5

Medication Dose Route Max duration Details
prEDNISone 60 mg/m² Once daily oral administration
Instructions:

Take in the morning with food.
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 6

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 7

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 8

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
metHOTREXATe * 20 mg/m² Once a week oral administration
Instructions:
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 2.5 mg tablets.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 9

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 10

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 11

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 12

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 13

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 14

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 15

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
metHOTREXATe * 20 mg/m² Once a week oral administration
Instructions:
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 2.5 mg tablets.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 16

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 17

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 18

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 19

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 20

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 21

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 22

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
metHOTREXATe * 20 mg/m² Once a week oral administration
Instructions:
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 2.5 mg tablets.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 23

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 24

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 25

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 26

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 27

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 28

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 29

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
metHOTREXATe * 20 mg/m² Once a week oral administration
Instructions:
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 2.5 mg tablets.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 30

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 31

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 32

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 33

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 34

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 35

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 36

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
metHOTREXATe * 20 mg/m² Once a week oral administration
Instructions:
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 2.5 mg tablets.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 37

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 38

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 39

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 40

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 41

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 42

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 43

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
metHOTREXATe * 20 mg/m² Once a week oral administration
Instructions:
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 2.5 mg tablets.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 44

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 45

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 46

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 47

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 48

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 49

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 50

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
metHOTREXATe * 20 mg/m² Once a week oral administration
Instructions:
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 2.5 mg tablets.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 51

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 52

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 53

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 54

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 55

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 56

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 57

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
metHOTREXATe * 20 mg/m² Once a week oral administration
Instructions:
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 2.5 mg tablets.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 58

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 59

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 60

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 61

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 62

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 63

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 64

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
metHOTREXATe * 20 mg/m² Once a week oral administration
Instructions:
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 2.5 mg tablets.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 65

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 66

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 67

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 68

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 69

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 70

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 71

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
metHOTREXATe * 20 mg/m² Once a week oral administration
Instructions:
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 2.5 mg tablets.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 72

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 73

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 74

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 75

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 76

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 77

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 78

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.
metHOTREXATe * 20 mg/m² Once a week oral administration
Instructions:
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 2.5 mg tablets.
  • Protect yourself from too much natural or artificial sunlight while being treated with this medicine.

Day: 79

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 80

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 81

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 82

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 83

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Day: 84

Medication Dose Route Max duration Details
mercaptOPURine 75 mg/m² Once daily oral administration
Instructions:
  • Take each dose on an empty stomach – one hour before OR three hours after food or milk.
  • Adjust dose to maintain neutrophils between 0.75 and 1.5 x 109/L and platelets between 75 and 150 x 109/L.
  • Round dose to closest multiple of 25 mg.
  • Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Supportive Care Factors

Factor Value
Antiviral prophylaxis for herpes virus: Routine antiviral prophylaxis recommended
Constipation risk: Consider prescribing laxatives with this treatment
Emetogenicity: Minimal to low
Gastroprotection: Gastroprotection is recommended
Pneumocystis jirovecii pneumonia (PJP) prophylaxis: Routine antibiotic prophylaxis recommended

Antiviral prophylaxis for hepatitis B virus: Guidance is limited to high-risk anti-cancer medicines. Clinicians will need to assess individual patient risk for other anti-cancer medicines.


Gastroprotection: Gastroprotection agents are only intended for short term use while patient is receiving corticosteroid treatment doses.


PJP prophylaxis: Avoid trimethoprim + sulfamethoxazole on the days oral metHOTREXATe is administered.

References

No references

* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.

s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.